Initial dose: Use 5 mL (1 tsp) per 5 US gallons (19 L). Maintenance dosing: Use 5 mL (1 tsp) per 10 US gallons (38 L) after regular maintenance, or at the interval of your choice. For a large livestock system or systems with heavy bioload, new system dosage may be safely increased up to 5x.

• For best results, add directly to aquarium in an area of high flow
• All chlorine and chloramines must be removed from water before adding FritzZyme 460
• Maintain adequate water flow or aeration
• Discontinue use of skimmer and UV sterilizers for at least 48 hours after application
• No contraindications: can be used with all of our other products and meds
• Safe for use with all species, including plants and invertebrates
• Safe to add directly into a tank with livestock present
• Variations of odor and color between bottles is normal, a strong sulfur smell does not mean the bacteria are dead
• Overdosed? Heterotrophic bacteria are very safe even if overdosed. Observe for any distress, increase aeration and perform small water changes if necessary